The toxicity associated with nickel (II) and chromium (VI) is mainly due to generation of reactive oxygen species (ROS) with subsequent oxidative deterioration of biological macromolecules.Both nickel and chromium can trip in the woods sierra nevada generate free radicals (FR) directly from molecular oxygen in a two step process to produce superoxide anion and in continued process, produce highly toxic hydroxyl radical.The pro-oxidative effects are compounded by fact that they also inhibit antioxidant enzymes and deplete intracellular glutathione.Garlic skincure cream (Allium sativum) has played an important dietary and medicinal role throughout the history of mankind.Garlic has the potential to enhance the endogenous antioxidant status in nickel as well as hexavalent chromium induced lipid peroxidation in normal and diabetic rats.